Factor IX (F9) Rabbit Polyclonal Antibody

CAT#: TA308875

Rabbit polyclonal antibody to Factor IX (coagulation factor IX)

Product Images

Sample (30 ug of whole cell lysate). A: 293T. 10% SDS PAGE. TA308875 diluted at 1:1000.

• 

  Immunohistochemical analysis of paraffin-embedded Colon ca, using Factor IX (TA308875) antibody at 1:250 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 217 and 453 of Factor IX (Uniprot ID#P00740)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: coagulation factor IX
• Database Link:
  NP_000124
  Entrez Gene 14071 MouseEntrez Gene 24946 RatEntrez Gene 404015 DogEntrez Gene 695578 MonkeyEntrez Gene 2158 Human
  UniProt ID P00740
• Background: This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq]
• Synonyms: FIX; HEMB; P19; PTC; THPH8
• Note: Seq homology of immunogen across species: Mouse (80%), Dog (87%), Monkey (96%), Pig (87%), Rabbit (82%), Rat (82%), Bovine (82%)

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades