KLRC4 Rabbit Polyclonal Antibody

CAT#: TA308966

Rabbit polyclonal antibody to KLRC4 (killer cell lectin-like receptor subfamily C, member 4)

Product Images

Sample (30 ug of whole cell lysate). A:293T. 12% SDS PAGE. TA308966 diluted at 1:1000

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 1 and 45 of KLRC4 (Uniprot ID#O43908)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 18 kDa
• Gene Name: killer cell lectin like receptor C4
• Database Link:
  NP_038459
  Entrez Gene 8302 Human
  UniProt ID O43908
• Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC4 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The 3' end of the KLRC4 transcript includes the first non-coding exon found at the 5' end of the adjacent D12S2489E gene transcript. [provided by RefSeq]
• Synonyms: NKG2-F; NKG2F
• Note: Seq homology of immunogen across species: Chimpanzee (100%)

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Antigen processing and presentation