G protein alpha Inhibitor 2 (GNAI2) Rabbit Polyclonal Antibody

CAT#: TA318889

Rabbit polyclonal anti-Gai2 antibody

Product Images

Western blot analysis of G alpha i2 expression in 3T3 cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4ug/ml, IP: 10-20ug/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 229 of human Gai2
• Formulation: 100 µg (0.5 mg/ml) affinity-purified rabbit anti-Gai2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: G protein subunit alpha i2
• Database Link:
  NP_002061
  Entrez Gene 2771 Human
  UniProt ID P04899
• Background: Gai2 is a 40-41 kDa alpha-subunit of heterotrimeric protein that shares sequence homology with Gai3 and Gai1. All these G proteins can be ADP-ribosylated at the carboxy terminal Cys of the CAAX sequence, interfering with receptor coupling. Gai2 is expressed widely in tissues and cell lines. Activation of PLC-β by Gai-coupled receptors is the result of release of Gβg subunits from Gai. Gai2 regulates potassium channel activation. Mutation at Arg179 has been identified in tumors. This and the Q205L mutant inhibit adenylyl cyclase.
• Synonyms: GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Axon guidance, Chemokine signaling pathway, Gap junction, Leukocyte transendothelial migration, Long-term depression, Melanogenesis, Progesterone-mediated oocyte maturation, Tight junction