FKBP38 (FKBP8) Rabbit Polyclonal Antibody

CAT#: TA318946

Rabbit polyclonal anti-FKBP38 antibody

Product Images

Western blot analysis of FKBP-38 with mouse intestine tissue lysate (left lane) and Jurkat cell lysate (Right lane).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 344 of mouse FKBP38
• Formulation: 100 µg (0.2mg/ml) protein A purified rabbit anti-FKBP38 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.1% BSA, 20% glycerol, and 0.02% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: FK506 binding protein 8
• Database Link:
  NP_036313
  Entrez Gene 14232 MouseEntrez Gene 290652 RatEntrez Gene 23770 Human
  UniProt ID Q14318
• Background: FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.
• Synonyms: FKBP38; FKBPr38

Reference Data

• Protein Families: Druggable Genome, Transmembrane