HDAC8 Rabbit Polyclonal Antibody

CAT#: TA319106

Rabbit polyclonal anti-HDAC8 antibody

Product Images

Western blot analysis using recombinant human HDAC8. Lane 1: 30 ng, Lane 2: 60 ng, Lane 3: 120 ng, Lane 4: 250 ng.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4 ug/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: E. coli-expressed recombinant human HDAC8
• Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: histone deacetylase 8
• Database Link:
  NP_001159890
  Entrez Gene 55869 Human
  UniProt ID Q9BY41
• Background: Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).
• Synonyms: CDA07; CDLS5; HD8; HDACL1; MRXS6; RPD3; WTS

Reference Data

• Protein Families: Druggable Genome, Transcription Factors