FGFR3 Rabbit Polyclonal Antibody

CAT#: TA319650

Rabbit Polyclonal FGFR3 Antibody

Product Images

Western blot analysis of FGFR3 in SK-N-SH cell lysate with FGFR3 antibody at (A) 0.5 and (B) 1 ug/mL.

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  Immunohistochemistry of FGFR3 in rat brain tissue with FGFR3 antibody at 2.5 ug/mL.

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  Immunofluorescence of FGFR3 in rat brain tissue with FGFR3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: FGFR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FGFR3.
• Formulation: FGFR3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: FGFR3 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 89 kDa; Observed: 9+2, 98 kDa
• Gene Name: fibroblast growth factor receptor 3
• Database Link:
  NP_000133
  Entrez Gene 14184 MouseEntrez Gene 84489 RatEntrez Gene 2261 Human
  UniProt ID P22607
• Background: FGFR3 Antibody: FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis (1). It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (1,2). It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia (3,4). Mutations in FGFR3 are also a cause of some bladder and cervical cancers (5).
• Synonyms: ACH; CD333; CEK2; HSFGFR3EX; JTK4

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Bladder cancer, Endocytosis, MAPK signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton