CtIP (RBBP8) Rabbit Polyclonal Antibody

CAT#: TA319698

Rabbit Polyclonal RBBP8 Antibody

Product Images

Western blot analysis of RBBP8 in mouse spleen tissue lysate with RBBP8 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of RBBP8 in rat spllen tissue with RBBP8 antibody at 5 ug/mL.

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  Immunofluorescence of RBBP8 in rat spleen tissue with RBBP8 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RBBP8 antibody was raised against a 14 amino acid synthetic peptide near the center of human RBBP8.
• Formulation: RBBP8 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: RBBP8 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: RB binding protein 8, endonuclease
• Database Link:
  NP_002885
  Entrez Gene 225182 MouseEntrez Gene 291787 RatEntrez Gene 5932 Human
  UniProt ID Q99708
• Background: RBBP8 Antibody: RBBP8, also known as CtBP (carboxy-terminal binding protein) interacting protein (CTIP), was characterized for its role in transcription as a cofactor for the transcriptional repressor CtBP, and also as a binding partner for other proteins including the cell cycle regulators retinoblastoma protein (Rb) and breast cancer 1 (BRCA1). It is ubiquitously expressed and localizes to the nucleus. RBBP8 is thought to modulate the functions in cell proliferation, transcriptional regulation and DNA repair. RBBP8 also plays a central role in the cell cycle checkpoint response to DNA double-stranded breaks (DSBs), with new evidence demonstrating that it controls the choice of DSB repair pathway.
• Synonyms: COM1; CTIP; JWDS; RIM; SAE2; SCKL2