SIVA (SIVA1) Chicken Polyclonal Antibody

CAT#: TA319827

Chicken Polyclonal SIVA Antibody

Product Images

Western blot analysis of SIVA in mouse liver tissue lysate with SIVA antibody at 1 ug/mL.

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  Immunofluorescence of SIVA in mouse liver cells with SIVA antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Chicken
• Isotype: IgY
• Clonality: Polyclonal
• Immunogen: SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA.
• Formulation: SIVA Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: SIVA Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SIVA1 apoptosis inducing factor
• Database Link:
  NP_006418
  Entrez Gene 30954 MouseEntrez Gene 10572 Human
  UniProt ID O15304
• Background: SIVA Antibody: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.
• Synonyms: CD27BP; SIVA; Siva-1; Siva-2

Reference Data

• Protein Families: Druggable Genome