SIRT1 Chicken Polyclonal Antibody

CAT#: TA319858

Chicken Polyclonal SIRT1 Antibody


USD 430.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1 ug/mL, IF: 20 ug/mL
Reactivities Human, Mouse, Rat
Host Chicken
Isotype IgY
Clonality Polyclonal
Immunogen SIRT1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human SIRT1.
Formulation SIRT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification SIRT1 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name sirtuin 1
Background SIRT1 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically via lysine residue.
Synonyms SIR2; SIR2alpha; SIR2L1
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.