IL17RA Rabbit Polyclonal Antibody

CAT#: TA319870

Rabbit Polyclonal IL-17RA Antibody

Product Images

Western blot analysis of IL17RA in A20 cell lysate with IL17RA antibody at 1 ug/mL.

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  Immunohistochemistry of IL-17RA in human spleen tissue with IL-17RA antibody at 2.5 ug/mL.

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  Immunofluorescence of IL-17RA in human spleen tissue with IL-17RA antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IL-17RA antibody was raised against an 18 amino acid peptide near the amino terminus of human IL-17RA.
• Formulation: IL-17RA Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: IL-17RA Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 95 kDa; Observed: 135 kDa
• Gene Name: interleukin 17 receptor A
• Database Link:
  NP_055154
  Entrez Gene 16172 MouseEntrez Gene 312679 RatEntrez Gene 23765 Human
  UniProt ID Q96F46
• Background: IL-17RA Antibody: Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1). It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1,2). IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3,4). Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5).
• Synonyms: CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction