Bcl2 Binding component 3 (BBC3) Mouse Monoclonal Antibody [Clone ID: 2A8F6]

CAT#: TA319889

Mouse PUMA Monoclonal Antibody

Product Images

Western blot analysis of PUMA expression in K562 cell lysate with PUMA antibody at (A) 2.5 and (B) 5 ug/mL.

Specifications

Product Data

• Clone Name: 2A8F6
• Applications: WB
• Recommended Dilution: WB: 2.5 - 5 ug/mL
• Reactivities: Human, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
• Formulation: PUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: BCL2 binding component 3
• Database Link:
  NP_001120712
  Entrez Gene 317673 RatEntrez Gene 27113 Human
  UniProt ID Q96PG8
• Background: PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
• Synonyms: JFY-1; JFY1; PUMA

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Huntington's disease, p53 signaling pathway