BANP Rabbit Polyclonal Antibody

CAT#: TA319948

Rabbit Polyclonal BANP Antibody

Product Images

Western blot analysis of BANP in mouse kidney tissue lysate with BANP antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of BANP in human kidney tissue with BANP antibody at 10 ug/mL.

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  Immunofluorescence of BANP in human kidney tissue with BANP antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: BANP antibody was raised against a 14 amino acid synthetic peptide near the center of human BANP.
• Formulation: BANP Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: BANP Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: BTG3 associated nuclear protein
• Database Link:
  NP_001167010
  Entrez Gene 53325 MouseEntrez Gene 292064 RatEntrez Gene 54971 Human
  UniProt ID Q8N9N5
• Background: BANP Antibody: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-beta signaling. Furthermore, BANP can modulate NF-κB transactivation and can inhibit tumorigenesis by regulating NF-κB target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.
• Synonyms: BEND1; SMAR1; SMARBP1