PTCHD2 (DISP3) Rabbit Polyclonal Antibody

CAT#: TA319981

Rabbit Polyclonal PTCHD2 Antibody

Product Images

Western blot analysis of PTCHD2 in mouse kidney tissue lysate with PTCHD2 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of PTCHD2 in human kidney tissue with PTCHD2 antibody at 2.5 ug/mL.

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  Immunofluorescence of PTCHD2 in human kidney tissue with PTCHD2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PTCHD2 antibody was raised against a 19 amino acid synthetic peptide from near the center of human PTCHD2.
• Formulation: PTCHD2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: PTCHD2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: dispatched RND transporter family member 3
• Database Link:
  NP_065831
  Entrez Gene 242748 MouseEntrez Gene 313705 RatEntrez Gene 57540 Human
  UniProt ID Q9P2K9
• Background: PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.
• Synonyms: PTCHD2

Reference Data

• Protein Families: Transmembrane