DISP2 Rabbit Polyclonal Antibody

CAT#: TA320064

Rabbit Polyclonal DISP2 Antibody

Product Images

Immunohistochemistry of DISP2 in human small intestine tissue with DISP2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DISP2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DISP2.
• Formulation: DISP2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Purification: DISP2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: dispatched RND transporter family member 2
• Database Link:
  NP_277045
  Entrez Gene 85455 Human
  UniProt ID A7MBM2
• Background: DISP2 Antibody: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.
• Synonyms: DISPB; HsT16908

Reference Data

• Protein Families: Transmembrane