Cd180 Rat Monoclonal Antibody [Clone ID: RP/14]

CAT#: TA320240

Rat Anti-Mouse CD180 (RP105) Purified (50 ug)

Product Images

Surface staining of mouse splenocytes with Anti-Mouse CD180 (RP105) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

Specifications

Product Data

• Clone Name: RP/14
• Applications: FC
• Recommended Dilution: Flow, Functional Assay, IP
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD180 antigen
• Database Link:
  NP_032559
  Entrez Gene 17079 Mouse
  UniProt ID Q62192
• Background: The RP/14 monoclonal antibody reacts with mouse CD180 (RP105). This 105 kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on mature B cells, monocytes/macrophages and dendritic cells. Ligation of RP105 with RP/14 protects B cells from irradiation- or dexamethasone-induced apoptosis, and drives them to proliferate. B cells activated by RP105-ligation arrest their growth and undergo apoptosis when the antigen receptor is engaged. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death.
• Synonyms: LY64; Ly78; MGC126233; MGC126234; RP105