Flt3 Rat Monoclonal Antibody [Clone ID: AFL4]

CAT#: TA320334

Rat Anti-Mouse VEGF Receptor 3 Purified (50 ug)

Specifications

Product Data

• Clone Name: AFL4
• Recommended Dilution: Flow, IHC, Functional Assay, IP, WB
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: FMS-like tyrosine kinase 3
• Database Link:
  NP_034359
  Entrez Gene 14255 Mouse
  UniProt ID Q00342
• Background: The AFL4 monoclonal antibody reacts with the mouse VEGF receptor-3, also known as Flt-4. This 195 kDa molecule was identified as an endothelial-specific member of the receptor tyrosine kinase (RTK) family. During early embryogenesis all endothelial cells express VEGFR-3, while in the adult tissues, VEGFR-3 expression disappears from the vascular endothelial cells and is observed only on the lymphatic endothelium. However, VEGFR-3 expression is induced in the adult tissue upon tumor implementation suggesting an important role for this receptor in the tumor angiogenesis. VEGF-C and VEGF-D bind to and activate VEGFR-3. AFL4 is an antagonist mAb.
• Synonyms: CD135; FLK2; STK-1; STK1