Lrrc36 Rat Monoclonal Antibody [Clone ID: B2D]

CAT#: TA320415

Rat Anti-Mouse ROR gamma (t) Purified (25 ug)

Product Images

Left: Mouse thymus (left) and spleen (right) nuclear cell lysates were loaded at 1x105 cells/lane, probed with 2 ug/mL of Anti-Mouse ROR gamma (t) Purified and revealed with Anti-Rat IgG HRP. Right: Untransfected (left) and mouse ROR gamma-transfected (right) 293T nuclear cell lysates were loaded at 1x105 cells/lane, probed with 2 ug/ml of Anti-Mouse ROR gamma (t) Purified and revealed with HRP anti-rat IgG.

Specifications

Product Data

• Clone Name: B2D
• Applications: WB
• Recommended Dilution: WB
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: leucine rich repeat containing 36
• Database Link:
  NP_001028543
  Entrez Gene 270091 Mouse
  UniProt ID Q3V0M2
• Background: The B2D monoclonal antibody reacts with the mouse RORγ(t) protein. RORγ is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes RORα and RORβ. ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed in several tissues including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, RORγt, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ ??ouble-positive??thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs. The RORγt isoform differs from RORγ by three unique amino acids at the amino terminus. Therefore, the B2D antibody will react with both the RORγ and RORγt isoforms.
• Synonyms: FLJ11004; RORBP70; XLHSRF2