Factor IX (F9) Rabbit Polyclonal Antibody

CAT#: TA321064

Anti-F9 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 227-461 amino acids of human coagulation factor IX
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: coagulation factor IX
• Database Link:
  NP_000124
  Entrez Gene 14071 MouseEntrez Gene 24946 RatEntrez Gene 2158 Human
  UniProt ID P00740
• Background: This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa; which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions; membrane phospholipids; and factor VIII. Alterations of this gene; including point mutations; insertions and deletions; cause factor IX deficiency; which is a recessive X-linked disorder; also called hemophilia B or Christmas disease.
• Synonyms: FIX; HEMB; P19; PTC; THPH8

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades