GNRHR Rabbit Polyclonal Antibody

CAT#: TA321121

Anti-GNRHR Rabbit Polyclonal Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane 1-2: PC-3 and LOVO cell lysates Primary antibody: TA321121 (GNRHR Antibody) at dilution 1/500 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 3 seconds

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA321121 (GNRHR Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA321121 (GNRHR Antibody) at dilution 1/40, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: PC-3 and LOVO cell lysates
  IHC: 50-300
  Positive control: Human tonsil
  Predicted cell location: Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 62-75 amino acids of Human gonadotropin-releasing hormone receptor
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 28 kDa
• Gene Name: gonadotropin releasing hormone receptor
• Database Link:
  NP_000397
  Entrez Gene 14715 MouseEntrez Gene 81668 RatEntrez Gene 2798 Human
  UniProt ID P30968
• Background: This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane; G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes; breast; ovary; and prostate. Following binding of gonadotropin-releasing hormone; the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
• Synonyms: GNRHR1; GRHR; HH7; LHRHR; LRHR

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: GnRH signaling pathway, Neuroactive ligand-receptor interaction