Myelin Protein Zero (MPZ) Rabbit Polyclonal Antibody

CAT#: TA321148

Anti-MPZ Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 5-20
  Positive control: Human cervical cancer
  Predicted cell location: Cell membrane, Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: myelin protein zero
• Database Link:
  NP_000521
  Entrez Gene 17528 MouseEntrez Gene 24564 RatEntrez Gene 4359 Human
  UniProt ID P25189
• Background: This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 and other polyneuropathies. The myelin sheath is a multi-layered membrane; unique to the nervous system; that functions as an insulator to greatly increase the velocity of axonal impulse conduction. The P0 glycoprotein; absent in the central nervous system;[1] is a major component of the myelin sheath in peripheral nerves. It comprises a large extracellular N-terminal domain; a single transmembrane (TM) region; and a smaller positively charged intracellular domain.
• Synonyms: CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; P0

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)