Myelin Protein Zero (MPZ) Rabbit Polyclonal Antibody

CAT#: TA321149

Anti-MPZ Rabbit Polyclonal Antibody


USD 345.00

In Stock*

Size
    • 100 ul

Product Images

Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 15-50
Positive control: Human thyroid cancer
Predicted cell location: Cell membrane, Cytoplasm
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Full length fusion protein
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name myelin protein zero
Background This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 and other polyneuropathies. The myelin sheath is a multi-layered membrane; unique to the nervous system; that functions as an insulator to greatly increase the velocity of axonal impulse conduction. The P0 glycoprotein; absent in the central nervous system;[1] is a major component of the myelin sheath in peripheral nerves. It comprises a large extracellular N-terminal domain; a single transmembrane (TM) region; and a smaller positively charged intracellular domain.
Synonyms CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; P0
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)

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