CD3D Rabbit Polyclonal Antibody

CAT#: TA321190

Anti-CD3D Rabbit Polyclonal Antibody

Product Images

Predicted band size: 19 kDa. Positive control: Jurkat and HuT-78 cell lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lane 1: Jurkat cell lysate Lane 2: HuT-78 cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 22-105 amino acids of human CD3d molecule, delta (CD3-TCR complex)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 19 kDa
• Gene Name: CD3d molecule
• Database Link:
  NP_000723
  Entrez Gene 12500 MouseEntrez Gene 25710 RatEntrez Gene 915 Human
  UniProt ID P04234
• Background: The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
• Synonyms: CD3-DELTA; IMD19; T3D

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway