PCB (PC) Rabbit Polyclonal Antibody

CAT#: TA321239

Anti-PC Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Hela cells
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 563-832 amino acids of human pyruvate carboxylase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 130 kDa
• Gene Name: pyruvate carboxylase
• Database Link:
  NP_000911
  Entrez Gene 25104 RatEntrez Gene 18517 MouseEntrez Gene 5091 Human
  UniProt ID P11498
• Background: This gene encodes pyruvate carboxylase; which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis; lipogenesis; insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs; but encoding the same protein; have been found for this gene.
• Synonyms: PCB

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Citrate cycle (TCA cycle), Metabolic pathways, Pyruvate metabolism