IL10RA Rabbit Polyclonal Antibody

CAT#: TA321372

Anti-IL10RA Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human tosil tissue using TA321372 (IL10RA Antibody) at dilution 1/60 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tosil tissue using TA321372 (IL10RA Antibody) at dilution 1/60, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human tosil
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 329 amino acids of Human Interleukin-10 receptor subunit alpha
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 10 receptor subunit alpha
• Database Link:
  NP_001549
  Entrez Gene 16154 MouseEntrez Gene 117539 RatEntrez Gene 3587 Human
  UniProt ID Q13651
• Background: The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10; and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants; one protein-coding and the other not protein-coding; have been found for this gene.
• Synonyms: CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway