Histone H2A.X (H2AFX) Rabbit Polyclonal Antibody

CAT#: TA321435

Anti-H2AFX Rabbit Polyclonal Antibody


USD 345.00

4 Weeks*

Size
    • 100 ul

Product Images

Other products for "H2AFX"

Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1:500-1000, IHC: 1:50-100, IF: 1:100-200
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Peptide sequence around aa.137~141 (Q-A-S-Q-E) derived from Human Histone H2A.X.
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 15 kDa
Gene Name H2A histone family member X
Background Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation
Synonyms H2A; H2A.X; H2AX; X
Reference Data
Protein Families Druggable Genome
Protein Pathways Systemic lupus erythematosus

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.