DR6 (TNFRSF21) Rabbit Polyclonal Antibody

CAT#: TA321835

Anti-TNFRSF21 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human fetal brain tissue
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 42-56 amino acids of Human tumor necrosis factor receptor superfamily, member 21
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 72 kDa
• Gene Name: tumor necrosis factor receptor superfamily member 21
• Database Link:
  NP_055267
  Entrez Gene 94185 MouseEntrez Gene 316256 RatEntrez Gene 27242 Human
  UniProt ID O75509
• Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK; and induce cell apoptosis. Through its death domain; this receptor interacts with TRADD protein; which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation; and may be involved in inflammation and immune regulation.
• Synonyms: BM-018; CD358; DR6

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction