Telomerase reverse transcriptase (TERT) Rabbit Polyclonal Antibody

CAT#: TA321951

Anti-TERT Rabbit Polyclonal Antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane: Human mucinous type of soft tissue sarcoma tissue lysate Primary antibody: TA321951 (TERT Antibody) at dilution 1/700 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 90 seconds

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  Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using TA321951 (TERT Antibody) at dilution 1/70 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using TA321951 (TERT Antibody) at dilution 1/70, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA321951 (TERT Antibody) at dilution 1/70 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA321951 (TERT Antibody) at dilution 1/70, treated with synthetic peptide. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: Human mucinous type of soft tissue sarcoma tissue lysate
  IHC: 100-300
  Positive control: Human colorectal cancer
  Predicted cell location: Nucleus and Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 1120-1132 amino acids of human telomerase reverse transcriptase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: telomerase reverse transcriptase
• Database Link:
  NP_937986
  Entrez Gene 21752 MouseEntrez Gene 301965 RatEntrez Gene 7015 Human
  UniProt ID O14746
• Background: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity; encoded by this gene; and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence; as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair; since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
• Synonyms: EST2; hEST2; TCS1; telomerase catalytic subunit; telomerase reverse transcriptase; TP2; TRT

Reference Data

• Protein Families: Druggable Genome