RAMP1 Rabbit Polyclonal Antibody

CAT#: TA322548

Anti-RAMP1 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 17 kDa. Positive control: Mouse testis tissue lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 minutes)

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  Predicted cell location: Membrane, Cytoplasm. Positive control: Human thyroid cancer tissue. Recommended dilution: 1/10-50 The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using RAMP1 antibody at dilution 1/10, on the right is treated with the fusion protein. (Original magnification:x200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1:1000-2000, WB: 1:200-1000, IHC: 1:10-50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 27-117 amino acids of human receptor (G protein-coupled) activity modifying protein 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 17 kDa
• Gene Name: receptor activity modifying protein 1
• Database Link:
  NP_005846
  Entrez Gene 51801 MouseEntrez Gene 58965 RatEntrez Gene 10267 Human
  UniProt ID O60894
• Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins; called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR; a receptor with seven transmembrane domains; can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor; depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein; CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation; maturation; and presentation of the CGRP receptor to the cell surface.
• Synonyms: receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; receptor-activity modifying protein 1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction