Deltex (DTX1) Rabbit Polyclonal Antibody

CAT#: TA322745

Anti-DXT1 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human brain tissue using TA322745 (DTX1 Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA322745 (DTX1 Antibody) at dilution 1/20, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human brain
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 50-64 amino acids of Human deltex homolog 1 (Drosophila)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: deltex 1
• Database Link:
  NP_004407
  Entrez Gene 14357 MouseEntrez Gene 687424 RatEntrez Gene 1840 Human
  UniProt ID Q86Y01
• Background: Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene. Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however; it may play a role in basic helix-loop-helix transcription factor activity. DTX1 has been shown to interact with EP300. Functions as an ubiquitin ligase protein in vivo; mediating ubiquitination and promoting degradation of MEKK1; suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
• Synonyms: hDx-1

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Notch signaling pathway