p95 NBS1 (NBN) Rabbit Polyclonal Antibody
Other products for "NBN"
Specifications
Product Data | |
Applications | IHC |
Recommended Dilution | IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 729-743 amino acids of human nibrin |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | nibrin |
Database Link | |
Background | Mutations in this gene are associated with Nijmegen breakage syndrome; an autosomal recessive chromosomal instability syndrome characterized by microcephaly; growth retardation; immunodeficiency; and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. |
Synonyms | AT-V1; AT-V2; ATV; NBS; NBS1; P95 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Homologous recombination |
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