GRK2 Rabbit Polyclonal Antibody

CAT#: TA323143

Anti-ADRBK1 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA323143 (GRK2 Antibody) at dilution 1/87 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA323143 (GRK2 Antibody) at dilution 1/87, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 100-300
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 644-659 amino acids of Human adrenergic, beta, receptor kinase 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: G protein-coupled receptor kinase 2
• Database Link:
  NP_001610
  Entrez Gene 25238 RatEntrez Gene 110355 MouseEntrez Gene 156 Human
  UniProt ID P25098
• Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
• Synonyms: ADRBK1; BARK1; BETA-ARK1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Chemokine signaling pathway, Endocytosis