CELSR2 Rabbit Polyclonal Antibody

CAT#: TA323174

Anti-CELSR2 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 2623-2639 amino acids of human cadherin, EGF LAG seven-pass G-type receptor 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cadherin EGF LAG seven-pass G-type receptor 2
• Database Link:
  NP_001399
  Entrez Gene 53883 MouseEntrez Gene 83465 RatEntrez Gene 1952 Human
  UniProt ID Q9HCU4
• Background: The protein encoded by this gene is a member of the flamingo subfamily; part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains; seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains; a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication; with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
• Synonyms: ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3

Reference Data

• Protein Families: Druggable Genome, Transmembrane