COX10 Rabbit Polyclonal Antibody

CAT#: TA323193

Anti-COX10 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human renal cancer tissue using TA323193 (COX10 Antibody) at dilution 1/100. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human renal cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to N terminal 300 amino acids of Human COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
• Database Link:
  NP_001294
  Entrez Gene 70383 MouseEntrez Gene 691853 RatEntrez Gene 1352 Human
  UniProt ID Q12887
• Background: Cytochrome c oxidase (COX); the terminal component of the mitochondrial respiratory chain; catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer; and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase; which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation; which results in the substitution of a lysine for an asparagine (N204K); is identified to be responsible for cytochrome c oxidase deficiency. In addition; this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
• Synonyms: COX10 homolog; cytochrome c oxidase assembly protein; cytochrome c oxidase subunit X; heme A: farnesyltransferase; heme A:farnesyltransferase; heme A: farnesyltransferase (yeast)

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Metabolic pathways, Oxidative phosphorylation, Porphyrin and chlorophyll metabolism