MYSM1 Rabbit Polyclonal Antibody

CAT#: TA323309

Anti-MYSM1 Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human ovarian cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 808-821 amino acids of Human Myb-like, SWIRM and MPN domains 1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Myb like, SWIRM and MPN domains 1
• Database Link:
  NP_001078956
  Entrez Gene 320713 MouseEntrez Gene 298247 RatEntrez Gene 114803 Human
  UniProt ID Q5VVJ2
• Background: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A; a specific tag for epigenetic transcriptional repression; thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Component of a large chromatin remodeling complex; at least composed of MYSM1; PCAF; RBM10 and KIF11/TRIP5. Binds histones
• Synonyms: 2A-DUB; 2ADUB

Reference Data

• Protein Families: Protease