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SPAG8 Rabbit Polyclonal Antibody
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Specifications
| Product Data | |
| Applications | ELISA, IHC |
| Recommended Dilution | IHC: 25-100 Positive control: Human tonsil Predicted cell location: Cytoplasm |
| Reactivities | Human, Mouse, Rat |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 205-426 amino acids of human sperm associated antigen 8 |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Gene Name | sperm associated antigen 8 |
| Database Link | |
| Background | The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility; as well as identification of proteins for targeted contraception; are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. |
| Synonyms | BS-84; HSD-1; hSMP-1; MGC26201; OTTHUMP00000021352; SMP1; SPAG3; sperm associated antigen 8; sperm membrane protein 1 |
| Reference Data | |
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