IL18BP Rabbit Polyclonal Antibody

CAT#: TA323375

Anti-IL18BP Rabbit Polyclonal Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: MCF-7 cell lysate Primary antibody: TA323375 (IL18BP Antibody) at dilution 1/900 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 10 seconds

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  Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA323375 (IL18BP Antibody) at dilution 1/65 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA323375 (IL18BP Antibody) at dilution 1/65, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: MCF-7 cell lysate
  IHC: 50-100
  Positive control: Human prostate cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 31-195 of Human Interleukin-18-binding protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 18 binding protein
• Database Link:
  NP_766631
  Entrez Gene 16068 MouseEntrez Gene 84388 RatEntrez Gene 10068 Human
  UniProt ID O95998
• Background: The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine; IL18. It binds IL18; prevents the binding of IL18 to its receptor; and thus inhibits IL18-induced IFN-gamma production; resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Synonyms: IL18BPa; interleukin 18 binding protein; MC51L-53L-54L homolog gene product; OTTHUMP00000179141; OTTHUMP00000179143; tadekinig-alfa

Reference Data

• Protein Families: Druggable Genome, Secreted Protein