Natriuretic Peptide Receptor A (NPR1) Rabbit Polyclonal Antibody

CAT#: TA323535

Anti-NPR1 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human brain tissue using TA323535 (NPR1 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA323535 (NPR1 Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA323535 (NPR1 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA323535 (NPR1 Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human brain
  Predicted cell location: Cytoplasm, Nucleus, Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 525-541 amino acids of Human natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: natriuretic peptide receptor 1
• Database Link:
  NP_000897
  Entrez Gene 18160 MouseEntrez Gene 24603 RatEntrez Gene 4881 Human
  UniProt ID P16066
• Background: Guanylyl cyclases; catalyzing the production of cGMP from GTP; are classified as soluble and membrane forms . The membrane guanylyl cyclases; often termed guanylyl cyclases A through F; form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain; a single membrane-spanning domain; and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962); which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295); respectively).
• Synonyms: ANPa; ANPRA; GUC2A; GUCY2A; NPRA

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Purine metabolism, Vascular smooth muscle contraction