Thyroid Peroxidase (TPO) Rabbit Polyclonal Antibody
Other products for "TPO"
Specifications
Product Data | |
Applications | IHC |
Recommended Dilution | IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Full length fusion protein |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | thyroid peroxidase |
Database Link | |
Background | This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones; thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis; including congenital hypothyroidism; congenital goiter; and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene; but the full-length nature of some variants has not been determined. |
Synonyms | MSA; TDH2A; TPX |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways | Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway, Metabolic pathways, Tyrosine metabolism |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.