AGXT Rabbit Polyclonal Antibody

CAT#: TA323756

Anti-AGXT Rabbit Polyclonal Antibody

Product Images

Predicted band size: 43 kDa. Positive control: Hela cell and human fetal liver tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane 1: Hela cell lysate Lane 2: Human fetal liver tissue lysate Lysates: 40 ug per lane Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:1000-2000, WB: 1:200-1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 280-294 amino acids of human alanine-glyoxylate aminotransferase
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 43 kDa
• Gene Name: alanine-glyoxylate aminotransferase
• Database Link:
  NP_000021
  Entrez Gene 11611 MouseEntrez Gene 24792 RatEntrez Gene 189 Human
  UniProt ID P21549
• Background: Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene. This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes; where it is involved in glyoxylate detoxification. Mutations in this gene; some of which alter subcellular targetting; have been associated with type I primary hyperoxaluria. Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate; and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.
• Synonyms: AGT; AGT1; AGXT1; PH1; SPAT; SPT; TLH6

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alanine, aspartate and glutamate metabolism, Glycine, serine and threonine metabolism, Metabolic pathways