PTP kappa (PTPRK) Rabbit Polyclonal Antibody

CAT#: TA323866

Anti-PTPRK Rabbit Polyclonal Antibody

Product Images

Predicted band size: 25 kDa. Positive control: Mouse liver tissue lysate. Recommended dilution: 1/500-2000. (Gel: 15%+12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/550 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 seconds)

• 

  Predicted cell location: Cytoplasm. Positive control: Human tonsil tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human tonsil tissue using PTPRK antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification: x200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1:2000-5000, WB: 1:500-2000, IHC: 1:25-100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 25 kDa
• Gene Name: protein tyrosine phosphatase, receptor type K
• Database Link:
  NP_001129120
  Entrez Gene 19272 MouseEntrez Gene 360302 RatEntrez Gene 5796 Human
  UniProt ID Q15262
• Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. This PTP possesses an extracellular region; a single transmembrane region; and two tandem catalytic domains; and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain; an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction; possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1; which may be important for the inhibition of keratinocyte proliferation.
• Synonyms: R-PTP-kappa

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Transmembrane