CDK5 Rabbit Polyclonal Antibody

CAT#: TA323962

Anti-CDK5 Rabbit Polyclonal Antibody

Product Images

Gel: 10+12%SDS-PAGE Lysate: 30 μg Lane 1-2: Human fetal brain tissue Human colon cancer tissue Primary antibody: TA323962 (CDK5 Antibody) at dilution 1/150 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 5 minutes

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323962 (CDK5 Antibody) at dilution 1/10 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323962 (CDK5 Antibody) at dilution 1/10, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Human fetal brain and colon cancer tissue
  IHC: 10-50
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 33 kDa
• Gene Name: cyclin-dependent kinase 5
• Database Link:
  NP_001157882
  Entrez Gene 12568 MouseEntrez Gene 140908 RatEntrez Gene 1020 Human
  UniProt ID Q00535
• Background: Cell division protein kinase 5?is an?enzyme?that in humans is encoded by the?CDK5?gene.?The protein encoded by this gene is part of the?cyclin-dependent kinase?family. CDK5 is required for proper development of the brain and to be activated; CDK5 must associate with CDK5R1 or CDK5R2. Cdk5 is involved in the processes of neuronal maturation and migration; phosphorylating the key intracellular adaptor of the reelin signaling chain. Experiments performed on mice lacking p35; a necessary activator of cdk5 in early brain development; showed that the normal layering of neurons was reversed in the cortex. This disrupted lamination again implicated cdk5 in neuronal migration and plasticity. Cdk5 is also involved in the regulation of synaptic vesicle exocytosis via phosphorylation of munc-18.
• Synonyms: PSSALRE

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Alzheimer's disease, Axon guidance