CNTF Receptor alpha (CNTFR) Rabbit Polyclonal Antibody

CAT#: TA324163

Anti-CNTFR Rabbit Polyclonal Antibody

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: HT29 and Hela cell lysate
  IHC: 100-300
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 23-342 amino acids of human ciliary neurotrophic factor receptor
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 41 kDa
• Gene Name: ciliary neurotrophic factor receptor
• Database Link:
  NP_001193940
  Entrez Gene 12804 MouseEntrez Gene 313173 RatEntrez Gene 1271 Human
  UniProt ID P26992
• Background: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor; which plays a critical role in neuronal cell survival; differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor; gp130 and leukemia inhibitory factor receptor; facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength; as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
• Synonyms: MGC1774

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway