Integrin beta 4 binding protein (EIF6) Rabbit Polyclonal Antibody

CAT#: TA324259

Anti-EIF6 Rabbit Polyclonal Antibody

Product Images

Predicted band size: 27 kDa. Positive control: COLO320 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 27 kDa
• Gene Name: eukaryotic translation initiation factor 6
• Database Link:
  NP_001254739
  Entrez Gene 16418 MouseEntrez Gene 305506 RatEntrez Gene 3692 Human
  UniProt ID P56537
• Background: Eukaryotic initiation factor 6 (eIF6) is reqiured for the 60S ribosomal subunit assembly in the nucleolus. In the cytoplasm, this protein is bound to 60S ribosome subunits and prevents them from joining 40S ribosome subunits to form 80S ribosomes. eIF6 is also shown to associate with the RNA-induced silencing complex (RISC). Deletion of eIF6 abolishes the miRNA-mediated gene silencing. eIF6 may play its essential role in miRNA-mediated silencing by inhibiting translation initiation or ribosome recycling.
• Synonyms: b(2)gcn; CAB; eIF-6; EIF3A; ITGB4BP; p27(BBP); p27BBP

Reference Data

• Protein Families: Druggable Genome