PKR (EIF2AK2) Rabbit Polyclonal Antibody

CAT#: TA325443

Rabbit Polyclonal PKR (Thr446) Antibody (Phospho-specific)

Product Images

Western blot analysis of PKR phosphorylation expression in Starvation treated K562 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against A synthesized peptide derived from human PKR around the phosphorylation site of Threonine 446
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 74 kDa
• Gene Name: eukaryotic translation initiation factor 2 alpha kinase 2
• Database Link:
  NP_001129123
  Entrez Gene 5610 Human
  UniProt ID P19525
• Background: PKR a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis.
• Synonyms: EIF2AK1; PKR; PPP1R83; PRKR

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors