LKB1 (STK11) Rabbit Polyclonal Antibody

CAT#: TA325911

Rabbit Polyclonal LKB1 (Ser428) Antibody (Phospho-specific)

Product Images

Western blot analysis of LKB1 phosphorylation expression in PMA treated HeLa whole cell lysates, The lane on the left is treated with the antigen-specific peptide.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:2000; IHC: 1:50-1:200; IF/ICC: 1:100-1:500
• Reactivities: Human, Mouse
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against A synthesized peptide derived from human LKB1 around the phosphorylation site of Serine 428
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 65 kDa
• Gene Name: serine/threonine kinase 11
• Database Link:
  NP_000446
  Entrez Gene 20869 MouseEntrez Gene 6794 Human
  UniProt ID Q15831
• Background: ubiquitously expressed kinase of the CAMKL family with a tumor suppressor activity. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. Strongest expression in testis and fetal liver. Mutations in LKB1 lead to the Peutz-Jeghers cancer syndrome.
• Synonyms: hLKB1; LKB1; PJS

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Adipocytokine signaling pathway, mTOR signaling pathway