p38 (MAPK14) Rabbit Polyclonal Antibody [Clone ID: N/A]

CAT#: TA326350

Rabbit polyclonal p38 Antibody

Product Images

Multi-blot analysis of p38 in a cell lysate from 12 human cancer cell lines using a 1:1000 dilution of the antibody

Specifications

Product Data

• Clone Name: N/A
• Applications: WB
• Recommended Dilution: WB: 1:5000, IP: 1:250
• Reactivities: Bovine, Canine, Chicken, Guinea Pig, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Sheep, Pig
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH.
• Formulation: Rabbit antiserum
• Concentration: lot specific
• Purification: Rabbit antiserum
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: mitogen-activated protein kinase 14
• Database Link:
  NP_001306
  Entrez Gene 26416 MouseEntrez Gene 81649 RatEntrez Gene 718976 MonkeyEntrez Gene 1432 Human
  UniProt ID Q16539
• Background: The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms . This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway . The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2 translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death . Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP . p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs . As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes .
• Synonyms: CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A
• Note: Detects a ~43kDa protein corresponding to the molecular mass of p38 on SDS PAGE immunoblots.

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway