HSP90AB1 Rabbit Polyclonal Antibody [Clone ID: N/A]

CAT#: TA326372

Rabbit polyclonal Hsp90 Antibody


USD 355.00

5 Days*

Size
    • 100 ul

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Specifications

Product Data
Clone Name N/A
Applications IF, WB
Recommended Dilution WB: 1:20,000-40,000
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Full length protein Hsp90
Formulation Rabbit antiserum
Concentration lot specific
Purification Rabbit antiserum
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name heat shock protein 90kDa alpha family class B member 1
Background Hsp90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex . Despite its label of being a heat-shock protein, hsp90 is one of the most highly expressed proteins in unstressed cells (12% of cytosolic protein). It carries out a number of housekeeping functions including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the hsp90-regulated proteins that have been discovered to date are involved in cell signaling . The number of proteins now know to interact with Hsp90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase.5. When bound to ATP, Hsp90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation.In most cases, hsp90-interacting proteins have been shown to co-precipitate with hsp90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in hsp90 expression or hsp90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit hsp90 function .
Synonyms D6S182; HSP84; HSP90B; HSPC2; HSPCB
Note Detects ~90kDa proteins corresponding to the molecular mass of Hsp90a/β.
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer

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