Hsp40 (DNAJB1) Rabbit Polyclonal Antibody [Clone ID: N/A]

CAT#: TA326377

Rabbit polyclonal Hsp40 Antibody

Product Images

Western blot analysis of Hsp40 in HeLa cell lysates using a 1:1000 dilution of the antibody

Specifications

Product Data

• Clone Name: N/A
• Applications: WB
• Recommended Dilution: WB: 1:1500-2000
• Reactivities: Human, Mouse, Rat, African Green Monkey
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant purified human hsp40
• Formulation: Rabbit antiserum
• Concentration: lot specific
• Purification: Rabbit antiserum
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: DnaJ heat shock protein family (Hsp40) member B1
• Database Link:
  NP_006136
  Entrez Gene 81489 MouseEntrez Gene 361384 RatEntrez Gene 718890 MonkeyEntrez Gene 3337 Human
  UniProt ID P25685
• Background: DnaJ/Hsp40 proteins have been preserved throughout evolution and are important for protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of chaperone proteins, Hsp70s. Because the ATP hydrolysis is essential for the activity of Hsp70s, DnaJ/Hsp40 proteins actually determine the activity of Hsp70s by stabilizing their interaction with substrate proteins. DnaJ/Hsp40 proteins all contain the J domain through which they bind to Hsp70s. Hsp40, also known as HDJ1 , is a basic mammalian 40kDa heat shock protein which is not only homologous to the bacterial heat shock protein (DnaJ), but also yeast DnaJ-related proteins such as SCJ1, Sec63/Npl1, YDJ1 and SIS1 . Hsp 40 is inducible by stress including heat after which is moves from the cytoplasm to the nucleus and nucleoli; an intracellular pattern similar to Hsc70/Hsp70, the mammalian homologues of the bacterial heat shock protein, DnaK .
• Synonyms: Hdj1; Hsp40; HSPF1; RSPH16B; Sis1
• Note: Detects an ~40kDa protein corresponding to the molecular mass of Hsp40 on SDS PAGE immunoblots. Also detects recombinant Hsp40.