Bim (BCL2L11) Rabbit Polyclonal Antibody [Clone ID: N/A]

CAT#: TA326412

Rabbit polyclonal BIM/BOD (IN) Antibody

Product Images

Western blot analysis of Bim in K562 (Left) and A549 (Right) whole cell lysates using a 1:1000 dilution of the antibody

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  IHC of Bim in human skin cancer cells using the antibody

Specifications

Product Data

• Clone Name: N/A
• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000, IHC: 1:50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Internal central amino acids of human Bim
• Formulation: PBS with 0.02% sodium azide
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: BCL2 like 11
• Database Link:
  NP_006529
  Entrez Gene 12125 MouseEntrez Gene 64547 RatEntrez Gene 10018 Human
  UniProt ID O43521
• Background: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat . Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines .
• Synonyms: BAM; BIM; BOD
• Note: Detects a 23kDa protein corresponding to the molecular mass of Bim on SDS PAGE immunoblots.

Reference Data

• Protein Families: Druggable Genome