Piccolo (PCLO) Rabbit Polyclonal Antibody
Other products for "PCLO"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | WB: 1:1000 |
Reactivities | Human, Mouse, Rat. Not yet tested on other species |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Full length protein |
Formulation | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
Concentration | lot specific |
Purification | Protein G Purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | piccolo presynaptic cytomatrix protein |
Database Link | |
Background | Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains . In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) . Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 . |
Synonyms | ACZ |
Note | Detects ~550kDa corresponding to the molecular weight of Picollo. Multiple isoforms can be detected. No cross-reactivity to Bassoon. |
Reference Data |
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